Morpholine → 5-Morpholino-2-nitroaniline
反応式
F[C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CN1C(=O)CCC1.O>[N:12]1([C:2]2[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1参加物
5
反応条件
- 温度
- 100 °C
実験手順
5-Fluoro-2-nitrophenylamine (1.0 eq) and morpholine (3.0 eq) were dissolved in NMP and heated at 100° C. for 1 hour. The solution was cooled to room temperature and diluted with water. The resulting precipitate was filtered and dried under vacuum to yield 5-morpholin-4-yl-2-nitrophenylamine. The resulting solid was recrystallized from EtOH to afford pure product as a bright yellow solid. LC/MS m/z 224.1 (MH+), Rt 1.89 minutes.
後処理
- temperatureThe solution was cooled to room temperature
- filtrationThe resulting precipitate was filtered
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-5010c61b75b7459d99ec891510de689d
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07138409B2
反応ノート
読み込み中…