Ethanol → 1-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole

反応式

[F:1][C:2]1[CH:3]=[C:4]([NH:11][NH2:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[N:13]1[CH:18]=CC=NN=1.[CH2:19](O)C>>[F:1][C:2]1[CH:3]=[C:4]([N:11]2[CH:18]=[N:13][CH:19]=[N:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

参加物

反応物 3

HCID 702Ethanol

HCID 1230471,2,3-Triazine

HCID 21883867(3-Fluoro-4-nitrophenyl)hydrazine

生成物 1

HCID 218839191-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole

実験手順

The mixture consisting of 2.5 g of 3-fluoro-4-nitrophenylhydrazine, 1.2 g of [1,2,3]triazine and 50 ml of ethanol was heated to reflux with stirring for 6 hours. After concentrating the reaction mixture under reduced pressure, the residue was worked up by column chromatography (solvent: 99:1 dichloromethane:methanol; silica gel).