N-methyl-2-pyrrolidone → 1-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide

HRID 722232ノート

反応式

HRID 722232 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[NH:12]1[CH2:20][CH2:19][CH2:18][CH:14]([C:15]([NH2:17])=[O:16])[CH2:13]1.CN1C(=O)CCC1>O>[F:8][C:5]1[CH:6]=[CH:7][C:2]([N:12]2[CH2:20][CH2:19][CH2:18][CH:14]([C:15]([NH2:17])=[O:16])[CH2:13]2)=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

参加物

5

反応物 3

HCID 13387N-methyl-2-pyrrolidoneHCID 677672,5-DifluoronitrobenzeneHCID 929803-Piperidinecarboxamide

生成物 1

HCID 218839121-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

The mixture consisting of 1.62 g of 2,5-difluoronitrobenzene, 1.9 g of nipecotamide and 10 ml of NMP was heated with stirring to 80° C. for 2 hours. After the mixture had been allowed to cool, 30 ml of water were added and the mixture was stirred at RT for 30 minutes. The precipitated solid was filtered off with suction and dried under reduced pressure.

後処理

  1. temperaturewas heated
  2. temperatureto cool
  3. stirringthe mixture was stirred at RT for 30 minutes
  4. filtrationThe precipitated solid was filtered off with suction
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-74461f99bffd49d08ace61153edfed1a
出典データセット
uspto-grants-2006_11
特許番号
US07138414B2

反応ノート

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