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Dimethylformamide → 3-Methyl-2-phenylvaleryl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 3-Methyl-2-phenylpentanoic acid | HCID 295961 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Methyl-2-phenylvaleryl chloride | HCID 21886026 | — |
反応手順
To a stirred solution of 3-methyl-2-phenylvaleric acid (1.23 g; 6.2 mmol) and a catalytic amount of dry dimethylformamide (ca. 20 μL) in 5 mL of dry methylene chloride under nitrogen at room temperature was added oxalyl chloride (4.8 mL of 2.0 M solution in methylene chloride) dropwise. After 45 minutes, the mixture was concentrated in vacuo and used immediately for Step 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07138529B2 |
| 出典データセット | uspto-grants-2006_11 |
| ORD ID | ord-2a4c185e9436403caedbe74555c00be8 |
| 出典メモ | uspto-grants-2006_11 |