Hydrochloric Acid → methyl 5-bromo-1H-indole-2-carboxylate

HRID 722775

反応式

HRID 722775 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=[O:12])=[CH:5]2.Cl.[CH3:15]O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13][CH3:15])=[O:12])=[CH:5]2

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2521375-Bromo-1H-indole-2-carboxylic acid

生成物 1

HCID 914343methyl 5-bromo-1H-indole-2-carboxylate

実験手順

A solution of 5-Bromo-1H-indole-2-carboxylic acid (commercial, 10.0 g, 41.6 mmol) in methanol (200 ml) was cooled to 0° C. and saturated with HCl(g). The resulting solution was allowed to warm gradually to room temperature overnight. The solvent was removed in vacuo and the residue treated with 0.88 ammonia (500 ml). The resulting solution was extracted with dichloromethane (3-fold 150 ml) and the combined organics dried (magnesium sulphate) and the solvent removed in vacuo to give the required product as a colourless oil (8.35 g).

後処理

  1. customThe solvent was removed in vacuo
  2. additionthe residue treated with 0.88 ammonia (500 ml)
  3. extractionThe resulting solution was extracted with dichloromethane (3-fold 150 ml)
  4. dry with materialthe combined organics dried (magnesium sulphate)
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-8189599a83054a6a8e67f3aeb8e2e22c
出典データセット
uspto-grants-2006_11
特許番号
US07138527B2

関連ノート

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