Water → N-(4-bromo-2-ethylphenyl)acetamide
反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH2:9][CH3:10])[CH:3]=1.C(N(CC)CC)C.[C:18](Cl)(=[O:20])[CH3:19].O>ClCCl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:18](=[O:20])[CH3:19])=[C:4]([CH2:9][CH3:10])[CH:3]=1参加物
6
実験手順
To a solution of 4-bromo-2-ethylaniline (50 g, 0.25 mol) in dichloromethane (250 ml) is added triethylamine (63.24 g, 0.62 mol) and the mixture is stirred at room temperature for 30 minutes. The reaction mixture is cooled to 0° C. and acetyl chloride (39.25 g, 0.5 mol) is added dropwise. The reaction mixture is stirred at 25-30° C. for 60 minutes, then poured into water, and the two phases separated. The organic phase is washed with water, dried over anhydrous sodium sulfate, filtered and the filtrate is evaporated under reduced pressure to yield N-(4-bromo-2-ethylphenyl)acetamide (40 g).
後処理
- temperatureThe reaction mixture is cooled to 0° C.
- stirringThe reaction mixture is stirred at 25-30° C. for 60 minutes
- customthe two phases separated
- washThe organic phase is washed with water
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- customthe filtrate is evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-e2a9b5b2b9234194b9d11bee1e03abde
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08828908B2
反応ノート
読み込み中…