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Methyl propionate → 3-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl propionate | HCID 11124 | — |
| 反応物 | 5-(4-Benzyloxyphenyl)-[1,3,4]oxathiazol-2-one | HCID 59549525 | — |
| 溶媒 | Chlorobenzene | HCID 7964 | — |
| 生成物 | 3-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester | HCID 66617751 | — |
反応手順
5-(4-benzyloxy-phenyl)-[1,3,4]oxathiazol-2-one (0.4 g, 1.4 mmol) and 0.23 ml of methyl propionate were dissolved in 10 ml of chlorobenzene and then refluxed overnight. The solvent was distilled off under reduced pressure and the obtained crude compound was purified by silica gel column chromatography to obtain 3-(4-benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester as a desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828992B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-bae299a0dd6140dd87b26a0cdc892800 |
| 出典メモ | uspto-grants-2014_09 |