1-[4-(2-Dimethylamino-ethylamino)-3-nitrophenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one → 1-[3-Amino-4-(2-dimethylaminoethylamino)phenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one

HRID 723330ノート

反応式

HRID 723330 の反応式
[CH3:1][N:2]([CH3:34])[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[CH:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:18]=3)[C:13]2=[O:30])=[CH:8][C:7]=1[N+:31]([O-])=O>ClCCl.C(O)(=O)C.[Zn]>[NH2:31][C:7]1[CH:8]=[C:9]([N:12]2[CH:16]=[CH:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:19][CH:18]=3)[C:13]2=[O:30])[CH:10]=[CH:11][C:6]=1[NH:5][CH2:4][CH2:3][N:2]([CH3:34])[CH3:1]

参加物

5

反応物 1

HCID 218733991-[4-(2-Dimethylamino-ethylamino)-3-nitrophenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one

生成物 1

HCID 218733231-[3-Amino-4-(2-dimethylaminoethylamino)phenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one

試薬・触媒・溶媒 3

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

Zinc dust (250 mg) was added to a solution of 1-[4-(2-dimethylamino-ethylamino)-3-nitrophenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one (50 mg) in dichloromethane (10 ml) and glacial acetic acid (1 ml). After 10 minutes, solids were removed by filtration and the filtrate was washed with saturated sodium carbonate solution. The organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 429.53 (C25H27N5O2); MS (ESI): 430 ([M+H]+), was obtained in this way.

後処理

  1. customsolids were removed by filtration
  2. washthe filtrate was washed with saturated sodium carbonate solution
  3. dry with materialThe organic phase was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customMS (ESI): 430 ([M+H]+), was obtained in this way

出典と根拠

ORDレコード
ord-adca3358e96b49a3acfa98a756ae33aa
出典データセット
uspto-grants-2006_11
特許番号
US07141561B2

反応ノート

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