Ammonia → 3,6-Dichloropyridazin-4-amine

HRID 723531ノート

反応式

HRID 723531 の反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[NH3:10]>>[NH2:10][C:7]1[CH:6]=[C:5]([Cl:9])[N:4]=[N:3][C:2]=1[Cl:1]

参加物

3

反応物 2

HCID 222AmmoniaHCID 951233,4,6-Trichloropyridazine

生成物 1

HCID 2984983,6-Dichloropyridazin-4-amine

実験手順

A suspension of 3,4,6-trichloropyridazine (prepared by the method of B. Kasnar et al, Nucleosides and Nucleotides, 1994, 13, 459) (10.0 g) in conc. aqueous ammonia (1 L) was heated at 75° C. for 16 h. The mixture was concentrated to a small volume and extracted several times with ethyl acetate. The extracts were washed with brine, dried and evaporated. The crude product was recrystallised from ethyl acetate to give the product (5.03 g).

後処理

  1. customprepared by the method of B
  2. concentrationThe mixture was concentrated to a small volume
  3. extractionextracted several times with ethyl acetate
  4. washThe extracts were washed with brine
  5. customdried
  6. customevaporated
  7. customThe crude product was recrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-cb541affb9eb4221b14af8d75c7103b1
出典データセット
uspto-grants-2006_11
特許番号
US07141564B2

反応ノート

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