Hydrogen Peroxide → Pyridine, 3-methoxy-, 1-oxide

HRID 723708

反応式

HRID 723708 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[OH:9]O>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[N+:5]([O-:9])[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 784Hydrogen PeroxideHCID 237193-Methoxypyridine

生成物 1

HCID 139850Pyridine, 3-methoxy-, 1-oxide収率 100%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
70 °C

実験手順

3-Methoxypyridine (20.08g, 209 mmol) was dissolved in 100 mL of acetic acid. 30% H2O2 (28.3 mL, 275 mmol) was added and the reaction mixture was heated at 70° C. for six h. The cooled reaction mixture was concentrated and the residue dissolved in CH2Cl2 and stirred overnight with 20 g of solid potassium carbonate. The mixture was filtered and concentrated to give compound 762A (25.2g, 100%) as a light yellow solid which was characterized by 1H NMR and carried on to the next step.

後処理

  1. customThe cooled reaction mixture
  2. concentrationwas concentrated
  3. dissolutionthe residue dissolved in CH2Cl2
  4. filtrationThe mixture was filtered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-4810d2db956f4b21951da1528e907e51
出典データセット
uspto-grants-2006_11
特許番号
US07141578B2

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