Hydrochloric Acid → HCID 69362923、化合物

HRID 723759ノート

反応式

HRID 723759 の反応式
C(OC([NH:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][N:26]4[CH:30]=[CH:29][N:28]=[N:27]4)[O:22][C:21]3=[O:31])=[CH:16][C:15]=2[F:32])[CH2:10]1)=O)(C)(C)C.Cl>ClCCl.C(O)C>[NH2:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][N:26]4[CH:30]=[CH:29][N:28]=[N:27]4)[O:22][C:21]3=[O:31])=[CH:16][C:15]=2[F:32])[CH2:10]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 69363436HCID 69363436、化合物

生成物 1

HCID 69362923HCID 69362923、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

(5R)-3-(4-((3R)-3-(t-Butoxycarbonyl)aminopyrrolidin-1-yl)-3-fluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)oxazolidin-2-one (532 mg, 1.2 mM), was dissolved in dichloromethane (10 ml), and treated with a solution of hydrogen chloride in ethanol (3.8M, 2 ml). After stirring 4 hours at ambient temperature, the precipitated hydrochloride of the product (230 mg) was filtered, and the filtrate diluted with diethyl ether to deposit more product (218 mg).

後処理

  1. filtrationthe precipitated hydrochloride of the product (230 mg) was filtered
  2. additionthe filtrate diluted with diethyl ether

出典と根拠

ORDレコード
ord-7e62cc9a17bf4be895321ad80fa0118d
出典データセット
uspto-grants-2006_11
特許番号
US07141583B2

反応ノート

読み込み中…