N-[(2-fluoro-5-nitrophenyl)carbamothioyl]benzamide → 5-Nitro-1,3-benzothiazol-2-amine
反応式
C[O-].[Na+].C([NH:12][C:13]([NH:15][C:16]1[CH:21]=[C:20]([N+:22]([O-:24])=[O:23])[CH:19]=[CH:18][C:17]=1F)=[S:14])(=O)C1C=CC=CC=1>CO>[N+:22]([C:20]1[CH:19]=[CH:18][C:17]2[S:14][C:13]([NH2:12])=[N:15][C:16]=2[CH:21]=1)([O-:24])=[O:23]参加物
4
実験手順
To a solution of methanol (1.6 L) was added sodium methoxide (8.64 g). While stirring, 1-benzoyl-3-(2-fluoro-5-nitro-phenyl)-thiourea (16 g) was added as a solid and the mixture stirred at room temperature for 17 hours. After this time, the reaction mixture was cooled in an ice bath and then filtered. The precipitate was washed with water (7.10 g, 86%). 1H-NMR δ: 8.05 (d, 1H, J=2.2 Hz), 7.97 (brs, 2H), 7.93 (s, 1H), 7.90 (d, 1H, J=2.2 Hz); MS (ESI) 195.8 (M+1, 100%).
後処理
- stirringthe mixture stirred at room temperature for 17 hours
- temperatureAfter this time, the reaction mixture was cooled in an ice bath
- filtrationfiltered
- washThe precipitate was washed with water (7.10 g, 86%)
出典と根拠
- ORDレコード
- ord-2bb3380b827d4311a12cc1309e178602
- 出典データセット
- uspto-grants-2006_11
- 特許番号
- US07141595B2
反応ノート
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