Methyl but-2-ynoate → Methyl 2-methyl-4-trimethylsilyloxybenzoate

HRID 724242

反応式

HRID 724242 の反応式
[CH3:1][Si:2]([CH3:11])([CH3:10])[O:3][C:4]1[CH:9]=CC[CH2:6][CH:5]=1.[C:12]([O:17][CH3:18])(=[O:16])[C:13]#[C:14][CH3:15]>C1(C)C=CC=CC=1>[CH3:15][C:14]1[CH:9]=[C:4]([O:3][Si:2]([CH3:11])([CH3:10])[CH3:1])[CH:5]=[CH:6][C:13]=1[C:12]([O:17][CH3:18])=[O:16]

参加物

4

反応物 2

HCID 141019Methyl but-2-ynoateHCID 40956562-(Trimethylsiloxy)-1,3-cyclohexadiene

生成物 1

HCID 21879730Methyl 2-methyl-4-trimethylsilyloxybenzoate収率 67.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
150 °C

実験手順

A 50 mL round bottom flask equipped with magnetic stir bar and condenser was charged with 6.0 g of 2-trimethylsilyloxy-1,3-cyclohexadiene, 3.5 g methyl tetrolate in 3 mL dry toluene. The reaction was heated to 150° C. for 50 hours at which point 1H-NMR indicated no starting diene. The raction was concentrated in vacuo to provide 5.7 g (67%) methyl 2-methyl-4-trimethylsilyloxybenzoate.

後処理

  1. customA 50 mL round bottom flask equipped with magnetic stir bar and condenser
  2. concentrationThe raction was concentrated in vacuo

出典と根拠

ORDレコード
ord-940abf4bfb13441ca0e82923ec97ca9d
出典データセット
uspto-grants-2006_11
特許番号
US07141609B2

関連ノート

読み込み中…