Hydrochloric Acid → 2-Amino-1-methylcyclohexanol hydrochloride

HRID 724263ノート

反応式

HRID 724263 の反応式
[ClH:1].[OH:2][C:3]1([CH3:17])[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[NH:9]C(=O)OC(C)(C)C>O1CCOCC1>[ClH:1].[NH2:9][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C:3]1([CH3:17])[OH:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 69571280Tert-butyl 2-hydroxy-2-methylcyclohexylcarbamate

生成物 1

HCID 218771592-Amino-1-methylcyclohexanol hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

4M Hydrochloric acid in dioxan (40 ml, 160 mmol) was added to a solution of the more polar disatereoisomer of tert-butyl 2-hydroxy-2-methylcyclohexylcarbamate (1.52 g, 6.63 mmol) in dioxan (5 ml). The mixture was stirred for 4 h then the solvent was removed under reduced pressure and the residue dried in vacuo to afford a single diastereoisomer of 2-amino-1-methylcyclohexanol hydrochloride (1.05 g) as a white solid.

後処理

  1. customthe solvent was removed under reduced pressure
  2. customthe residue dried in vacuo

出典と根拠

ORDレコード
ord-be71f59583b743a6bbecdda020a7870b
出典データセット
uspto-grants-2006_11
特許番号
US07141586B2

反応ノート

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