Trimethylsilyldiazomethane → Methyl 2-chloro-5-fluoronicotinate
反応式
[Cl:1][C:2]1[N:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12][Si](C=[N+]=[N-])(C)C>>[Cl:1][C:2]1[N:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4]([O:6][CH3:12])=[O:5]参加物
3
実験手順
The title compound (D69) (0022/105/1) (1.8 g) was prepared according to the experimental procedure described in Description 66 starting from 2-Chloro-5-fluoronicotinic acid (2 g, 11.39 mmol) and trimethylsilyldiazomethane (2M solution in diethyl ether) (17 ml, 34.18 mmol)
出典と根拠
- ORDレコード
- ord-3f6d446cdb1b4a22937cf879919aa8b4
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08828987B2
反応ノート
読み込み中…