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Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| 反応物 | tert-Butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate | HCID 65813955 | — |
| 生成物 | Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate | HCID 67958200 | 60.3% |
反応手順
The title compound (D81) (0021/074/1) (75.9 mg) was prepared according to the experimental procedure described in Description 80 starting from tert-butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate (D29) (100 mg, 0.374 mmol) and methyl 2,5-dichloronicotinate (77.32 mg, 0.374 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828987B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-d3bb85cc8ad3477ba58a356b34090d63 |
| 出典メモ | uspto-grants-2014_09 |