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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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Hydrochloric Acid → 3-[4-(2-Tert-butyl-1,1,3-trioxo-2,3-dihydro-1h-1lambda6-isothiazol-5-yl)-phenyl]-2-(3-trifluoromethyl-benzenesulfonylamino)-propionimidic acid ethyl ester hydrochloride

HRID 724607
ノート
印刷プレビュー

反応式

HRID 724607 の反応式
[C:1]([N:5]1[C:9](=[O:10])[CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=3)(=[O:24])=[O:23])[C:19]#[N:20])=[CH:13][CH:12]=2)[S:6]1(=[O:36])=[O:35])([CH3:4])([CH3:3])[CH3:2].[ClH:37].[CH2:38]([OH:40])[CH3:39]>C(Cl)Cl>[ClH:37].[CH2:38]([O:40][C:19](=[NH:20])[CH:18]([NH:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:32])[F:33])[CH:26]=1)(=[O:24])=[O:23])[CH2:17][C:14]1[CH:13]=[CH:12][C:11]([C:7]2[S:6](=[O:35])(=[O:36])[N:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:9](=[O:10])[CH:8]=2)=[CH:16][CH:15]=1)[CH3:39]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 69597741n-{2-[4-(2-Tert-butyl-1,1,3-trioxo-2,3-dihydro-1h-1lambda6-isothiazol-5-yl)-phenyl]-1-cyano-ethyl}-3-trifluoromethyl-benzenesulfonamide

生成物 1

HCID 695977733-[4-(2-Tert-butyl-1,1,3-trioxo-2,3-dihydro-1h-1lambda6-isothiazol-5-yl)-phenyl]-2-(3-trifluoromethyl-benzenesulfonylamino)-propionimidic acid ethyl ester hydrochloride

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒
2 回

実験手順

A solution of 1.37-C of Step 3 (87 mg, 0.16 mmol) in methylene chloride (5 mL) and ethanol (0.2 mL) was treated with HCl gas for 1 h. Additional methylene chloride was added during the reaction to replenish the amount which was evaporated during the bubbling of HCl. The reaction mixture was concentrated and used immediately in the next reaction.

後処理

  1. customwas evaporated during the
  2. custombubbling of HCl
  3. concentrationThe reaction mixture was concentrated
  4. customused immediately in the next reaction

出典と根拠

ORDレコード
ord-f3c9b1e24d3646ebb7394aa7c6d658eb
出典データセット
uspto-grants-2006_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07141596B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート