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2,4-Difluorophenol → 5-Chloro-2-(3-(2,4-difluorophenoxy)azetidin-1-yl)nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Difluorophenol | HCID 123051 | — |
| 反応物 | Methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate | HCID 86697874 | — |
| 生成物 | 5-Chloro-2-(3-(2,4-difluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958422 | 86.8% |
反応手順
The title compound (D108) (84 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D63) (100 mg, 0.311 mmol) and 2,4-Difluorophenol (0.027 ml, 0.284 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828987B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-44d3865ae6cf493b9657033d0acad975 |
| 出典メモ | uspto-grants-2014_09 |