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3,4-Difluorophenol → 5-Chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-Difluorophenol | HCID 75927 | — |
| 反応物 | Methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate | HCID 86697874 | — |
| 生成物 | 5-Chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958520 | 89.9% |
反応手順
The title compound (D109) (87 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D63) (100 mg, 0.311 mmol) and 3,4-Difluorophenol (36.87 mg, 0.284 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828987B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c5af9a5393f64c708a00179f31e6aee7 |
| 出典メモ | uspto-grants-2014_09 |