4-Bromobenzenesulfonamide → 4-(4-Hydroxymethylphenyl)phenylsulfonamide

反応式

CS([C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=O)=O.BrC1C=CC([S:26]([NH2:29])(=[O:28])=[O:27])=CC=1>>[OH:18][CH2:17][C:14]1[CH:13]=[CH:12][C:11]([C:7]2[CH:6]=[CH:5][C:10]([S:26]([NH2:29])(=[O:28])=[O:27])=[CH:9][CH:8]=2)=[CH:16][CH:15]=1

参加物

反応物 2

HCID 696964-Bromobenzenesulfonamide

HCID 21879230(3'-Methanesulfonyl-biphenyl-4-yl)-methanol

生成物 1

HCID 566046214-(4-Hydroxymethylphenyl)phenylsulfonamide

実験手順

This compound was prepared in a manner analogous to the preparation of (3′-methanesulfonyl-biphenyl-4-yl)-methanol (WO 01/70753, Example 27) using 4-bromo-benzenesulfonamide as the starting material. LCMS found for C13H13NO3SNa (M+Na)+: m/z=286.

出典と根拠

ORDレコード: ord-7fa4a11014a341da894603fc0a1cbdb4
出典データセット: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07141596B2

反応ノート

読み込み中…