4-Chlorophenol → 2-(3-(4-Chlorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

HRID 72472

反応式

HRID 72472 の反応式
CS([O:5][CH:6]1[CH2:9][N:8]([C:10]2[N:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:11]=2[C:12]([O:14]C)=[O:13])[CH2:7]1)(=O)=O.[Cl:24][C:25]1[CH:30]=[CH:29][C:28](O)=[CH:27][CH:26]=1>>[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([O:5][CH:6]2[CH2:9][N:8]([C:10]3[N:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:11]=3[C:12]([OH:14])=[O:13])[CH2:7]2)=[CH:27][CH:26]=1

参加物

3

反応物 2

HCID 46844-ChlorophenolHCID 86697871Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate

生成物 1

HCID 679586912-(3-(4-Chlorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid収率 130%

実験手順

The title compound (D123) (125 mg) was prepared according to the experimental procedure described in Description 103A vero starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 4-Chlorophenol (0.033 ml, 0.338 mmol).

出典と根拠

ORDレコード
ord-c66810eb130e4cec8af6c7d29a71d62c
出典データセット
uspto-grants-2014_09
特許番号
US08828987B2

関連ノート

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