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HRID 72474作成日：2026年10月26日

4-Fluoro-3-(trifluoromethyl)phenol → 2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

https://huagongshe.com/reaction/72474

反応式

関与物質

役割名称HCID仕込み量
反応物4-Fluoro-3-(trifluoromethyl)phenolHCID 601854—
反応物Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinateHCID 86697871—
生成物2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acidHCID 8669787598.7%

反応手順

The title compound (D125) (108 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 4-Fluoro-3-(trifluoromethyl)phenol (60.98 mg, 0.338 mmol).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08828987B2
出典データセットuspto-grants-2014_09
ORD IDord-79e437b0e96046e6aff8e2a56f024a1e
出典メモuspto-grants-2014_09