1,2-O-dioleyl-3-O-tritylglycerol → 2,3-Bis[(9Z)-9-octadecen-1-yloxy]-1-propanol

HRID 724756

反応式

HRID 724756 の反応式
[CH2:1]([O:19][CH2:20][CH:21]([CH2:41][O:42]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClC(Cl)(Cl)C(O)=O.C(Cl)Cl>[CH2:1]([O:19][CH2:20][CH:21]([CH2:41][OH:42])[O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]\[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

参加物

3

反応物 1

HCID 702527781,2-O-dioleyl-3-O-tritylglycerol

生成物 1

HCID 53803432,3-Bis[(9Z)-9-octadecen-1-yloxy]-1-propanol収率 87%

試薬・触媒・溶媒 1

HCID 19349592Trichloroacetic acid methylene chloride溶媒

実験手順

1,2-O-Dioleyl-3-O-tritylglycerol (6.10 g, 7.3 mmol) was reacted with 5% trichloroacetic acid/methylene chloride (50 ml, w/v) at ambient temperature for 1 hour. The organic layer was then washed with saturated aqueous sodium hydrogen carbonate solution and water, dried, and concentrated. The residue was purified by column chromatography (silica gel/chloroform) to provide 3.75 g (87%) of the title compound.

後処理

  1. washThe organic layer was then washed with saturated aqueous sodium hydrogen carbonate solution and water
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography (silica gel/chloroform)

出典と根拠

ORDレコード
ord-c1a07edf93274ff392e5f0ec1c77a155
出典データセット
uspto-grants-1998_01
特許番号
US05705188

関連ノート

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