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p-Toluenesulfonic acid → 3-Ethoxycarbonyl-3-(4-nitrophenyl)propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | (4-Nitrophenyl)acetate | HCID 6931101 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 3-Ethoxycarbonyl-3-(4-nitrophenyl)propionic acid | HCID 11807640 | — |
反応手順
Following a similar procedure to that described in reference example 7b, but starting fromethyl 4-nitrophenylacetate instead of ethyl diphenylacetate, and hydrolizing then the tert-butyl ester using p-toluenesulfonic acid in benzene at reflux instead of using trifluoroacetic acid, the title compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05705504 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-c2c552ccf12b44bfa6feed885d81df99 |
| 出典メモ | uspto-grants-1998_01 |