Ethylamine → 2-Ethylamino-3-nitropyridine
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]参加物
3
反応条件
- 温度
- 105 °C
実験手順
A stirred mixture of 2-chloro-3-nitropyridine (50.0 g, 0.32 mol), ethylamine (33.5 g, 0.74 mol), and xylenes (85 mL) was heated at 105° C. in a sealed vessel for three hours. After cooling, the solvent was removed in vacuo, and water was added to the residue. The product was extracted with methylene chloride, dried (sodium sulfate), and concentrated in vacuo to give 56.8 g of the title compound as a brown oil, suitable for use in the next reaction.
後処理
- temperatureAfter cooling
- customthe solvent was removed in vacuo, and water
- additionwas added to the residue
- extractionThe product was extracted with methylene chloride
- dry with materialdried (sodium sulfate)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-fd116ade73e84ac4897a647ad04306d3
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05705499
反応ノート
読み込み中…