Triethylamine → HCID 45082394、化合物

HRID 724995

反応式

HRID 724995 の反応式
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[CH2:10](N(CC)CC)[CH3:11]>C(O)C.Cl>[CH3:10][CH2:11][O:8][C:7](=[O:9])[C@@H:2]([CH2:3][C:4]([OH:6])=[O:5])[NH2:1]

参加物

5

反応物 2

HCID 8471TriethylamineHCID 83887D-Aspartic Acid

生成物 1

HCID 45082394HCID 45082394、化合物収率 71%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒2 回

実験手順

13.31 g of D-aspartic acid (0.1 mole) are dissolved in 135 ml of absolute ethanol containing 8.7 g of dry hydrogen chloride. The reaction mixture is stirred for about 2 hr. The solution is diluted by addition of 250 ml of absolute ethanol. Triethylamine is then added dropwise until the solution becomes alkaline. After standing for 16 hr at +4° C., the obtained crystals are filtered, washed successively with cold absolute ethanol and ether, then dried. The reaction yields 11.5 g of D-aspartic acid β-ethyl ester (71%).

後処理

  1. waitAfter standing for 16 hr at +4° C.
  2. filtrationthe obtained crystals are filtered
  3. washwashed successively with cold absolute ethanol and ether
  4. customdried

出典と根拠

ORDレコード
ord-6624f76bdaf74ef0a4b527870acddc6a
出典データセット
uspto-grants-1998_01
特許番号
US05705522

関連ノート

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