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Methyl 4-(aminomethyl)benzoate hydrochloride → Methyl 4-((5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)methyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(aminomethyl)benzoate hydrochloride | HCID 2729253 | — |
| 反応物 | 5-Chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958861 | — |
| 生成物 | Methyl 4-((5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)methyl)benzoate | HCID 67958190 | 76% |
反応手順
The title compound (D157) (55 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-chloro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid (D103) (50 mg, 0.154 mmol) and Methyl 4-(aminomethyl)benzoate hydrochloride (31.24 mg, 0.154 mmol, available at Aldrich#328383).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828987B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-6fec37722d114c3c89411e26257d38c3 |
| 出典メモ | uspto-grants-2014_09 |