Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 67958766、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10]2[N:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:11]=2[C:12](O)=[O:13])[CH2:7]1.Cl.[NH2:27][C:28]1([C:31]2[CH:40]=[CH:39][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:33][CH:32]=2)[CH2:30][CH2:29]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10]2[N:18]=[CH:17][C:16]([C:19]([F:20])([F:21])[F:22])=[CH:15][C:11]=2[C:12]([NH:27][C:28]2([C:31]3[CH:40]=[CH:39][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:33][CH:32]=3)[CH2:30][CH2:29]2)=[O:13])[CH2:7]1参加物
3
実験手順
The title compound (D172) (60 mg) was prepared according to the experimental procedure described in Description 146 starting from 2-(3-(3-fluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D121) (50 mg, 0.14 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (31.95 mg, 0.14 mmol).
出典と根拠
- ORDレコード
- ord-a7838005109b47cf94bd215854749c2d
- 出典データセット
- uspto-grants-2014_09