Sulfuryl chloride → 2-Chloro-5-(chloromethyl)-1,3-thiazole--hydrogen chloride (1/1)
反応式
[Cl:1][CH2:2][CH:3]=[CH:4][N:5]=[C:6]=[S:7].S(Cl)([Cl:11])(=O)=O>ClCCCl>[ClH:1].[Cl:11][C:6]1[S:7][C:3]([CH2:2][Cl:1])=[CH:4][N:5]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
To a solution of 45 g of 3-chloroprop-1-enyl isothiocyanate in 90 ml of 1,2-dichloroethane, 50.5 g of sulphuryl chloride was added over 10 hours at -10° C. The reaction mixture was allowed to warm to 25° C. overnight, to complete the reaction. The solution was cooled to -15° C. and the product, a pale yellow solid, was isolated by filtration and washed with hexane. 38.2 g of 2-chloro-5-(chloromethyl) thiazole hydrochloride was thus obtained, having a melting point of 59°-61° C. and being a yield of 61.6%.
後処理
- customthe reaction
- temperatureThe solution was cooled to -15° C.
- customthe product, a pale yellow solid, was isolated by filtration
- washwashed with hexane
出典と根拠
- ORDレコード
- ord-896c39ed1fdd4775a7cc875d55948e95
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05705652
反応ノート
読み込み中…