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Tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate → Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate | HCID 24902824 | — |
| 反応物 | Methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate | HCID 86697873 | — |
| 生成物 | Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate | HCID 67958339 | 42.9% |
反応手順
The title compound (D200) (38 mg) was prepared according to the experimental procedure described in Description 160 starting from tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate (D40) (100 mg, 0.338 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D97) (61.8 mg, 0.169 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828987B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-3c29f907b93249e18648fce3fe9ec4c5 |
| 出典メモ | uspto-grants-2014_09 |