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(2-Phenylethyl)thiourea → 3-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Phenylethyl)thiourea | HCID 735845 | — |
| 反応物 | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 3-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide | HCID 21459205 | — |
反応手順
A suspension of 13.8 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 9.0 g of 1-(phenethyl)-2-thiourea in 150 ml of n-butanol and the mixture is heated to boiling under reflux for 3 hours. After cooling to room temperature, the crystals are filtered under suction and crystallized from n-butanol. There is obtained 3-nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide of m.p. 249°-251°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05705703 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-bde888d1d961431a9319617657e06e89 |
| 出典メモ | uspto-grants-1998_01 |