(2-Phenylethyl)thiourea → 3-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide

HRID 725421

反応式

HRID 725421 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[CH2:16]([NH:24][C:25]([NH2:27])=[S:26])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)CCC>[BrH:1].[N+:11]([C:9]1[CH:10]=[C:5]([C:3]2[N:27]=[C:25]([NH:24][CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[S:26][CH:2]=2)[CH:6]=[C:7]([OH:15])[C:8]=1[OH:14])([O-:13])=[O:12]

参加物

4

反応物 2

HCID 735845(2-Phenylethyl)thioureaHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

生成物 1

HCID 214592053-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A suspension of 13.8 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 9.0 g of 1-(phenethyl)-2-thiourea in 150 ml of n-butanol and the mixture is heated to boiling under reflux for 3 hours. After cooling to room temperature, the crystals are filtered under suction and crystallized from n-butanol. There is obtained 3-nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide of m.p. 249°-251°.

後処理

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. filtrationthe crystals are filtered under suction
  4. customcrystallized from n-butanol

出典と根拠

ORDレコード
ord-bde888d1d961431a9319617657e06e89
出典データセット
uspto-grants-1998_01
特許番号
US05705703

関連ノート

読み込み中…