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HRID 72543作成日：2026年10月26日

(R)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate → (R)-methyl 4-(1-(5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/72543

反応式

関与物質

役割名称HCID仕込み量
反応物(R)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylateHCID 67958316—
反応物Methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoateHCID 86697873—
生成物(R)-methyl 4-(1-(5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoateHCID 67966692106.4%

反応手順

The title compound (D205) (96 mg) was prepared according to the experimental procedure described in Description 160 starting from (R)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate (D47) (100 mg, 0.355 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D97) (D021/056/3) (65 mg, 0.177 mmol).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08828987B2
出典データセットuspto-grants-2014_09
ORD IDord-459729c531784e3c839137aab443158b
出典メモuspto-grants-2014_09