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Potassium Carbonate → 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Hydroxy-4-methoxybenzyl alcohol | HCID 78089 | — |
| 反応物 | 1-Bromo-3-methoxypropane | HCID 524551 | — |
| 反応物 | Ethyl acetate hexane | HCID 21226206 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol | HCID 45108163 | — |
反応手順
7.7 g of 3-hydroxy-4-methoxy-benzyl alcohol, 10.35 g of potassium carbonate and 12.1 g of 1-bromo-3-methoxy-propane are stirred under reflux in 150 ml of acetone for 3 days. After evaporation of the solvent, water is added to the residue and extraction is carried out with ethyl acetate. After evaporation of the solvent the title compound is obtained from the organic extracts by means of FC (240 g of silica gel, dichloromethane/methanol=96:4): Rf (ethyl acetate/hexane=2:1)=0.31.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05705658 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-e9a862e4a98840e394058be5794fdefd |
| 出典メモ | uspto-grants-1998_01 |