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Acetyl chloride → n-Acetyl-4-(2-tert-butoxycarbonylaminoethyl)-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-(2-Aminoethyl)piperidine, 4-BOC protected | HCID 1501849 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | n-Acetyl-4-(2-tert-butoxycarbonylaminoethyl)-piperidine | HCID 21458620 | — |
反応手順
0.5 g of 4-(2-tert-butoxycarbonylaminoethyl)-piperidine and 0.61 ml of triethylamine are dissolved in 5 ml of dichloromethane and, at 0° C., 0.22 ml of acetyl chloride is added. The reaction mixture is stirred at room temperature for 7 hours and then washed with water. The organic phase is concentrated by evaporation and purified by FC (10 g of silica gel, ethyl acetate/methanol=9:1). The title compound is obtained: Rf (ethyl acetate/methanol=9:1)=0.39.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05705658 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-1e0dad00f5eb4065a2020491b3ae2166 |
| 出典メモ | uspto-grants-1998_01 |