Hydrochloric Acid → (S)-Indoline-2-carboxylic acid ethyl ester
反応式
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C@H:3]1[C:11]([OH:13])=[O:12].[CH2:14](O)[CH3:15]>>[CH2:14]([O:12][C:11]([C@@H:3]1[CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[NH:2]1)=[O:13])[CH3:15]参加物
4
実験手順
HCl gas was bubbled through a stirring suspension of (S)-indoline-2-carboxylic acid (20 g, 110 mmol) in ethanol (500 mL). When the acid was completely dissolved, the solution was brought to reflux. After 16 hours, the solution was cooled and the solvent removed in vacuo. The residue was triturated with diethyl ether and the resulting off-white solid was collected by filtration, washed with hexanes and dried overnight in a vacuum oven at 30° C. to give (S)-indoline-2-carboxylic acid ethyl ester.HCl (25.7 g, 78%).
後処理
- dissolutionWhen the acid was completely dissolved
- temperatureto reflux
- temperaturethe solution was cooled
- customthe solvent removed in vacuo
- customThe residue was triturated with diethyl ether
- filtrationthe resulting off-white solid was collected by filtration
- washwashed with hexanes
- customdried overnight in a vacuum oven at 30° C.
出典と根拠
- ORDレコード
- ord-28152977512f494eaac0d27c93c9f79f
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05707966
反応ノート
読み込み中…