Methyl 3-oxoheptanoate → HCID 178441198、化合物

HRID 725815ノート

反応式

HRID 725815 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.O=[C:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10](OC)=[O:11]>C1(C)C=CC=CC=1>[CH2:14]([C:8]1[CH:9]=[C:10]([OH:11])[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=1)[CH2:15][CH2:16][CH3:17]

参加物

4

反応物 2

HCID 546075Methyl 3-oxoheptanoateHCID 178418806HCID 178418806、化合物

生成物 1

HCID 178441198HCID 178441198、化合物収率 80.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

A solution of 100 g of 3-aminopyrazole and 190 g of methyl 3-oxoheptanoate in 120 ml of toluene was refluxed with heating at 100° C. for 3 hours and then cooled. Toluene was distilled off under reduced pressure and diethyl ether was added to the residue. The crystals precipitated were collected and washed with diethyl ether and acetonitrile to provide 184 g of 5-n-butyl-7-hydroxypyrazolo[1,5-a]pyrimidine as colorless crystals.

後処理

  1. temperaturecooled
  2. distillationToluene was distilled off under reduced pressure and diethyl ether
  3. additionwas added to the residue
  4. customThe crystals precipitated
  5. customwere collected
  6. washwashed with diethyl ether and acetonitrile

出典と根拠

ORDレコード
ord-71d73ca6f2c044b58efa7b273705b756
出典データセット
uspto-grants-1998_01
特許番号
US05707997

反応ノート

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