Aniline → (2S,4R)-2-Anilinomethyl-N-t-butoxycarbonyl-4-t-butyldimethylsiloxypyrrolidine

HRID 725943

反応式

HRID 725943 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:14][C@H:13]([O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17])[CH2:12][C@H:9]1[CH:10]=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[NH:23]([CH2:10][C@@H:9]1[CH2:12][C@@H:13]([O:15][Si:16]([C:19]([CH3:22])([CH3:20])[CH3:21])([CH3:18])[CH3:17])[CH2:14][N:8]1[C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

3

反応物 2

HCID 6115AnilineHCID 10969557tert-Butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-formylpyrrolidine-1-carboxylate

生成物 1

HCID 57283160(2S,4R)-2-Anilinomethyl-N-t-butoxycarbonyl-4-t-butyldimethylsiloxypyrrolidine収率 82%

実験手順

(2S,4R)-2-Anilinomethyl-N-t-butoxycarbonyl-4-t-butyldimethylsiloxypyrrolidine (995 mg, yield: 82%) was prepared as a yellow oily substance, from (2S,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsiloxyprolinal (990 mg, 3 mmol) and aniline (0.3 ml, 3.3 mmol), in the same manner as in Reference Example 95-2.

出典と根拠

ORDレコード
ord-9770d381dfb140d5ae8ddf9de57590f9
出典データセット
uspto-grants-1998_01
特許番号
US05707987

関連ノート

読み込み中…