Acetamide, 2-bromo-N-butyl-N-methyl- → 2-(acetylthio)-N-butyl-N-methylacetamide
反応式
Br[CH2:2][C:3]([N:5]([CH2:7][CH2:8][CH2:9][CH3:10])[CH3:6])=[O:4].[C:11]([O-:14])(=[S:13])[CH3:12].[K+]>CO>[C:11]([S:13][CH2:2][C:3]([N:5]([CH2:7][CH2:8][CH2:9][CH3:10])[CH3:6])=[O:4])(=[O:14])[CH3:12]参加物
4
反応条件
- 温度
- 40 °C
実験手順
4.16 g of bromo-N-butyl-N-methylacetamide of Preparation B of Example 78, Step A in 1.5 ml of methanol were added to a suspension of 2.28 g of potassium thioacetate in 10 ml of methanol and the mixture was heated for one hour at 40° C. under an argon atmosphere. After evaporation to dryness under reduced pressure, the residue was dissolved with ethyl ether, the insoluble part filtered off and the solution was evaporated to dryness to obtain 4.06 g of oily product.
後処理
- customAfter evaporation to dryness under reduced pressure
- dissolutionthe residue was dissolved with ethyl ether
- filtrationthe insoluble part filtered off
- customthe solution was evaporated to dryness
出典と根拠
- ORDレコード
- ord-99a1a93eaf454df29261b73484e74e28
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05707982
反応ノート
読み込み中…