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2-Propenoic acid, 3-(2-chloro-4-fluorophenyl)- → 3-(2-Chloro-4-fluorophenyl)propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Propenoic acid, 3-(2-chloro-4-fluorophenyl)- | HCID 2725065 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum oxide monohydrate | HCID 86587499 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(2-Chloro-4-fluorophenyl)propanoic acid | HCID 11769583 | 101.4% |
反応手順
A mixture of 2-chloro-4-fluorocinnamic acid (22.9 g, 0.11 mol) and platinum oxide hydrate (0.5 g, EM Scientific) in 95% ethanol (140 ml) was placed on a Parr hydrogenation apparatus. After the appropriate amount of hydrogen was taken up, the catalyst was filtered and the mixture was concentrated in vacuo to give 22.6 g (98%) of 3-(2-chloro-4-fluorophenyl)propanoic acid as a purple solid. This material was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05708033 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-42500ebc25824cfa82c7d3a5689ba03c |
| 出典メモ | uspto-grants-1998_01 |