化工社化工社 化学情報印刷レポート · 研究参考用
2,6-Dibromopyridine → 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Dibromopyridine | HCID 12274 | — |
| 反応物 | 4-Aminotetrahydropyran | HCID 419223 | — |
| 試薬 | Cesium carbonate | HCID 10796 | — |
| 触媒 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | HCID 63962797 | 0% |
反応手順
to 2,6-dibromopyridine (100 mg, 0.42 mmol), 4-Aminotetrahydropyran (42.7 mg, 0.42 mmol) in dioxane (3 mL) while bubbling N2 was added Xantphos (24.43 mg, 0.04 mmol), CS2CO3 (316 mg, 0.97 mmol) and palladium(II) acetate (9.48 mg, 0.04 mmol). This was heated in a microwave at 130 oC for 30 mins. A small peak corresponding to product was obseved. Discontinued
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|---|
| ORD ID | ord-13cef69f8e724020954e5476c0d66794 |
| 出典メモ | 750 AstraZeneca ELN dataset |