関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 3-Formylphenylboronic acid | HCID 2734356 | — |
| 反応物 | 2-Amino-5-bromo-3-iodobenzenesulphonic acid | HCID 18919385 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Sodium 2-amino-5-bromo-3'-formyl[1,1'-biphenyl]-3-sulphonate | HCID 23687033 | — |
反応手順
A mixture of 11.34 g (30 mmol) of 2-amino-5-bromo-3-iodobenzenesulphonic acid, 4.5 g (30 mmol) of 3-formylbenzeneboronic acid, 10.5 g (99 mmol) of sodium carbonate and 1.73 g (1.5 mmol) of tetrakis(triphenylphosphine)palladium (0) in 40 ml of dimethylformamide and 20 ml of water is heated at 70° C. under argon for 5 hours. The reaction medium is then concentrated under reduced pressure and the residue is purified by chromatography on an RP 18 column, eluting with a water-acetonitrile mixture (8:2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05712393 |
|---|
| 出典データセット | uspto-grants-1998_01 |
|---|
| ORD ID | ord-92a8fa4b0e33450eab77cc719d12fa31 |
|---|
| 出典メモ | uspto-grants-1998_01 |
|---|
