Ethanol → Ethyl 3-Fluoro-4-nitrobenzoate
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([O:7][CH2:19][CH3:20])=[O:6]参加物
4
実験手順
To the liquid mixture of 3-fluoro-4-nitrobenzoic acid 9.71 g and ethanol 35 mL, cone. sulfuric acid 1.6 mL was added, followed by 16 hours' heating under reflux. After distilling the solvent off, water and tert-butyl methyl ether were added to the residue. The organic layer was extracted, washed with water and dried over magnesium sulfate. Distilling the solvent off, 7.40 g of the title compound was obtained.
後処理
- temperature' heating
- temperatureunder reflux
- distillationAfter distilling the solvent off, water and tert-butyl methyl ether
- additionwere added to the residue
- extractionThe organic layer was extracted
- washwashed with water
- dry with materialdried over magnesium sulfate
- distillationDistilling the solvent off, 7.40 g of the title compound
- customwas obtained
出典と根拠
- ORDレコード
- ord-2186fce3620a40909637c4fd0559f38d
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829000B2
反応ノート
読み込み中…