Ethanol → Ethyl 3-Fluoro-4-nitrobenzoate

HRID 72765

反応式

HRID 72765 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([O:7][CH2:19][CH3:20])=[O:6]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 2306533-Fluoro-4-nitrobenzoic acid

生成物 1

HCID 45036938Ethyl 3-Fluoro-4-nitrobenzoate

実験手順

To the liquid mixture of 3-fluoro-4-nitrobenzoic acid 9.71 g and ethanol 35 mL, cone. sulfuric acid 1.6 mL was added, followed by 16 hours' heating under reflux. After distilling the solvent off, water and tert-butyl methyl ether were added to the residue. The organic layer was extracted, washed with water and dried over magnesium sulfate. Distilling the solvent off, 7.40 g of the title compound was obtained.

後処理

  1. temperature' heating
  2. temperatureunder reflux
  3. distillationAfter distilling the solvent off, water and tert-butyl methyl ether
  4. additionwere added to the residue
  5. extractionThe organic layer was extracted
  6. washwashed with water
  7. dry with materialdried over magnesium sulfate
  8. distillationDistilling the solvent off, 7.40 g of the title compound
  9. customwas obtained

出典と根拠

ORDレコード
ord-2186fce3620a40909637c4fd0559f38d
出典データセット
uspto-grants-2014_09
特許番号
US08829000B2

関連ノート

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