化工社化工社 化学情報印刷レポート · 研究参考用
Ethoxyethylamine → N-(2-ethoxyethyl)-3-fluoro-4-nitrobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethoxyethylamine | HCID 66970 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Fluoro-4-nitrobenzoic acid | HCID 230653 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(2-ethoxyethyl)-3-fluoro-4-nitrobenzamide | HCID 59198706 | — |
反応手順
3-Fluoro-4-nitrobenzoic acid 5.55 g, 2-ethoxyethylamine 3.15 mL, N,N-diisopropylethylamine 5.23 mL, 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride 8.63 g, 1-hydroxybenzotriazole monohydrate 5.96 g and acetonitrile 77 mL were mixed and stirred for 19 hours. The reaction liquid was poured in diluted hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine, saturated aqueous sodium hydrogencarbonate solution and saturated brine, by the order stated, and dried over magnesium sulfate. Distilling the solvent off, 6.86 g of the title compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829000B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c289596415db46dba95edc6d7a6a7ad7 |
| 出典メモ | uspto-grants-2014_09 |