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Potassium Carbonate → Ethyl 3-[1-(4-fluoro-2-nitrophenyl)-1H-imidazol-2-yl]-propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Dimethylacetamide | HCID 31374 | — |
| 反応物 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 反応物 | Ethyl 3-(1H-imidazol-2-YL)propanoate | HCID 22259341 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl 3-[1-(4-fluoro-2-nitrophenyl)-1H-imidazol-2-yl]-propanoate | HCID 59198877 | 47.8% |
反応手順
1,4-Difluoro-2-nitrobenzene 239 mg, ethyl 3-(1H-imidazol-2-yl)propanoate 252 mg, potassium carbonate 415 mg and N,N-dimethylacetamide 10 mL were heated at 100° C. for 64 hours. The reaction liquid was diluted with ethyl acetate and filtered. The filtrate was condensed under reduced pressure and subjected to silica gel chromatography (ethyl acetate) to provide 220 mg of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829000B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c19c4eac2dda416aa93ff52de31f7662 |
| 出典メモ | uspto-grants-2014_09 |