Potassium Carbonate → HCID 59198914、化合物

HRID 72772

反応式

HRID 72772 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[NH:14]1[CH:18]=[CH:17][N:16]=[C:15]1[CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22].C(=O)([O-])[O-].[K+].[K+].CN(C)C(=O)C>C(OCC)C>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([N:14]2[CH:18]=[CH:17][N:16]=[C:15]2[CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=1)(=[O:10])[CH3:9]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 31374DimethylacetamideHCID 27346124'-Fluoro-3'-nitroacetophenoneHCID 22259341Ethyl 3-(1H-imidazol-2-YL)propanoate

生成物 1

HCID 59198914HCID 59198914、化合物収率 69%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4′-fluoro-3′-nitroacetophenone 2.04 g, ethyl 3-(1H-imidazol-2-yl)propanoate 1.87 g, potassium carbonate 3.07 g and N,N-dimethylacetamide 28 mL was heated at 100° C. for 16.5 hours. The reaction liquid was allowed to cool off and to which 60 mL of diethyl ether was added, followed by filtration. Adding 100 mL of water to the filtrate, the organic layer was separated. The aqueous layer was extracted with 100 mL of diethyl ether. The extract was combined with the organic layer, washed twice with 20 mL of water and once with 10 mL of saturated brine by the order stated, and dried over magnesium sulfate. Distilling the solvent off under reduced pressure, 2.54 g of the title compound was obtained.

後処理

  1. customThe reaction liquid
  2. additionwas added
  3. filtrationfollowed by filtration
  4. additionAdding 100 mL of water to the filtrate
  5. customthe organic layer was separated
  6. extractionThe aqueous layer was extracted with 100 mL of diethyl ether
  7. washwashed twice with 20 mL of water and once with 10 mL of saturated brine by the order
  8. dry with materialdried over magnesium sulfate
  9. distillationDistilling the solvent off under reduced pressure

出典と根拠

ORDレコード
ord-26b8b4cf5263426fbdedf8d120e736dd
出典データセット
uspto-grants-2014_09
特許番号
US08829000B2

関連ノート

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