関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylate | HCID 1113514 | — |
| 反応物 | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate | HCID 59198650 | 47.7% |
反応手順
Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08829000B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-fb2dddac9b4b492ab2f73cd7baa61606 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
