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Acetic Anhydride → Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-(Ethyl(2-hydroxyethyl)amino)benzaldehyde | HCID 639857 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Benzaldehyde, 4-[[2-(acetyloxy)ethyl]ethylamino]- | HCID 11458991 | — |
反応手順
To a stirred solution of 193.2 g (1 mole) of 4-(N-2-hydroxyethyl-N-ethylamino)benzaldehyde in dichloromethane are added 153.1 g (1.5 moles) of acetic anhydride, 151.8 g (1.5 moles) of triethylamine, and 8.5 g (7 mole %) of 4-N,N-dimethylaminopyridine. The reaction mixture is stirred at room temperature for 16 hours. The product solution then is washed with cold 2N HCl followed by saturated sodium bicarbonate, and the organic layer is filtered through cotton, and evaporated to dryness.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05044725 |
| 出典データセット | uspto-grants-1991_09 |
| ORD ID | ord-7b16f812848842e7b74bc72ac5d97a46 |
| 出典メモ | uspto-grants-1991_09 |