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Thionyl Chloride → 2,6-Difluorophenylacetyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2,6-Difluorophenylacetic acid | HCID 123585 | — |
| 生成物 | 2,6-Difluorophenylacetyl chloride | HCID 2758321 | — |
反応手順
75.3 g (0.44 mol) of 2,6-difluorophenylacetic acid are dissolved in 96 ml (156.5 g; 1.32 mol) of thionyl chloride, stirred for 1 hour at 60° and then heated under reflux for 2 hours. The excess thionyl chloride is then distilled off and the residue is fractionated, yielding 79.5 g (95% of the theoretical yield) of 2,6-difluorophenylacetyl chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05045556 |
| 出典データセット | uspto-grants-1991_09 |
| ORD ID | ord-6c85fe6bc8664cbe91c309939c981546 |
| 出典メモ | uspto-grants-1991_09 |