4-[1-(1-Imidazolyl)-butyl]-benzonitrile → 4-[1-(1-Imidazolyl)butyl]-benzaldehyde

HRID 727848ノート

反応式

HRID 727848 の反応式
[N:1]1([CH:6]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#N)=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)=[O:19].O>[Al].[Ni]>[N:1]1([CH:6]([C:10]2[CH:17]=[CH:16][C:13]([CH:14]=[O:19])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 2

HCID 145143624-[1-(1-Imidazolyl)-butyl]-benzonitrileHCID 18673298Formic acid--water (1/1)

生成物 1

HCID 145143774-[1-(1-Imidazolyl)butyl]-benzaldehyde

試薬・触媒・溶媒 1

HCID 6336846Nickel aluminide触媒

実験手順

10 g of nitrile of example 4 is refluxed with 10 g of aluminum nickel alloy in 150 ml of formic acid/water (75:25) for 1 hour. It is filtered on kieselguhr, the filtrate is alkalized with solid potassium carbonate, 100 ml of aqueous ammonia is added and extracted with ether. After drying and concentration by evaporation of the ether, it is distilled on a bulb tube; 9.1 g of 4-[1-(1-imidazolyl)butyl]-benzaldehyde is obtained, melting 200° C./0.03 mbar.

後処理

  1. filtrationIt is filtered on kieselguhr
  2. additionis added
  3. extractionextracted with ether
  4. customAfter drying
  5. concentrationconcentration
  6. customby evaporation of the ether, it
  7. distillationis distilled on a bulb tube

出典と根拠

ORDレコード
ord-a1e772603d33436ba04f83519ca41b85
出典データセット
uspto-grants-1991_09
特許番号
US05045558

反応ノート

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